Anti-Human CD273 （B7-DC） Biotin
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Anti-Human CD273 (B7-DC) Biotin ebioscience
產品名稱：Anti-Human CD273 (B7-DC) Biotin ebioscience
產品貨號：13-5888-80
產品規(guī)格：25 ug
產品品牌:eBioscience
Details
| Host | Mouse |
|---|---|
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Conjugate | Biotin |
| Reported Applications | Flow Cytometric Analysis |
Description
Description: The MIH18 monoclonal antibody reacts with human B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximay 25 kDa and belongs to the Ig superfamily. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. MIH18 is a useful tool for studies to elucidate the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in humans. MIH18 is a blocking antibody.
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