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Anti-Human Nanog Purified ebioscience


產(chǎn)品名稱(chēng):Anti-Human Nanog Purified ebioscience
產(chǎn)品貨號(hào):14-5768-80
產(chǎn)品規(guī)格:25 ug
產(chǎn)品品牌:eBioscience

 

Details

 

 

HostMouse
IsotypeIgG1, kappa
ReactivityHuman
ConjugatePurified
Reported ApplicationsImmunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections, Immunocytochemistry, Western Blotting

 

 

Description

 

 

Description: The hNanog.2 antibody recognizes human Nanog, a homeobox transcription factor expressed in embryonic stem cells (ESC). Nanog is essential for self-renewal of ESC and the inner cell mass and is throught to function in the same capacity as other factors such as Oct4 and Sox2. Nanog plays a crucial role in embryonic cell fate specification following formation of the blastocyst by regulating proliferation and preventing differentiation. Nanog functions by directly binding DNA consensus sequences to activate or repress transcription. In differentiating ESC, Nanog binds to its own promoter leading to repression of expression. Nanog has been reported to be overexpressed in germ cell tumors of the gonads and central nervous system as well as breast and colorectal cancer.

 


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