產品名稱：PAD4 Autoantibody EIA Kit
產品價格：5950
產    地：Cayman
產品貨號：500930
產品規(guī)格：96 wells
產品說明：
Synonyms Peptidylartginine Deaminase 4
Protein Arginine Deiminase 4
PAD4 Autoantibody ELISA Kit
Stability 6 months
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere 
Description
Protein arginine deiminase 4 （peptidylarginine deiminase 4 （PAD4））, is a guanidino-modifying enzyme which catalyzes the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 activity is increased in rheumatoid arthritis （RA）, producing citrulline-containing proteins （CCP） that induce the formation of arthritogenic autoantibodies. In addition to anti-CCP autoantibodies, 23-45% of RA patients also produce autoantibodies specific for the PAD4 enzyme itself. Cayman’s PAD4 Autoantibody EIA Kit is an immunometric assay which can be used to measure anti-PAD4 autoantibodies of any isotype （IgM, IgG, and IgA） in human plasma and serum without prior sample purification. Affinity-purified anti-PAD4 antibody isolated from the plasma of a patient with RA is used as the standard. One unit is approximay equal to 1 ng of anti-PAD4 Ig protein. The standard curve spans the range of 0-1,000 U/ml, with an LLOQ of 31.3 U/ml.