S0B5521 Rabbit Anti-FMC63 Antibody (S-2163-77)
- 公司名稱 杭州斯達特生物科技有限公司
- 品牌 Starter/斯達特
- 型號 S0B5521
- 產(chǎn)地 浙江 杭州
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2025/6/11 9:28:48
- 訪問次數(shù) 47
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FMC63 scFv (single-chain variable fragment) is a recombinant protein derived from the variable regions (VH and VL) of the anti-CD19 monoclonal antibody FMC63, linked by a flexible peptide spacer (e.g., (Gly?Ser)?). It specifically binds to the B-cell surface antigen CD19 with high affinity (KD ~1-10 nM) and is a key targeting component in FDA-approved CAR-T therapies, such as Kymriah?. The humanized FMC63 scFv retains potent antigen recognition while minimizing immunogenicity, making it highly effective in treating B-cell malignancies, including acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Ongoing research focuses on optimizing its affinity, stability, and functionality to enhance the safety and efficacy of CAR-T cell therapies.
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