Ku-80 Monoclonal Antibody
抗體,，也叫免疫球蛋白（Ig）,，是一種能特異性結(jié)合抗原的糖蛋白,，而抗原是在易感染動(dòng)物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì),。在體內(nèi),，抗體是由于外源性分子的侵襲而產(chǎn)生的,。抗體以一個(gè)或者多個(gè)Y字形單體存在,，每個(gè)Y字形單體由4條多肽鏈組成,，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來(lái)命名的,。Y字形結(jié)構(gòu)的頂端是可變區(qū),，為抗原結(jié)合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異）,，每一個(gè)抗體的重鏈則決定了它的類或型,。
產(chǎn)品詳情
Ku-80 Monoclonal Antibody detects endogenous levels of Ku-80 protein.
免疫原詳細(xì)信息
Purified recombinant fragment of human Ku-80 expressed in E. Coli.
相關(guān)試劑
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
背景
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
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