Protoxin II / ProTx-II 

Na_v1.7 selective inhibitor(鈉離子通道Nav1.7選擇性抑制劑)

ProTx-II (ProTx-2, Protoxin II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx-II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels.ProTx-II inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-II blocks Na_v1.7 with an IC₅₀ value of around 300 pM, Na_v1.2, Na_v1.5 and Na_v1.6 with IC₅₀ values of 41 nM, 79 nM and 26 nM respectively. It also acts on Ca_v3.1/CACNA1G and interacts more weakly with the related T-Type channel Ca_v3.2/CACNA1H but potently inhibits the L-type calcium channel Ca_v1.2/CACNA1C. ProTx-II blocks action potential propagation in nociceptors.

ProTx-II 技術資料

氨基酸序列：

Tyr-Cys²-Gln-Lys-Trp-Met-Trp-Thr-Cys⁹-Asp-Ser-Glu-Arg-Lys-Cys¹⁵-Cys¹⁶-Glu-Gly-Met-Val-Cys²¹-Arg-Leu-Trp-Cys²⁵-Lys-Lys-Lys-Leu-Trp-OH 

二硫鍵：Cys²-Cys¹⁶, Cys⁹-Cys²¹ and Cys¹⁵-Cys²⁵ 

長度 (aa)： 30 

分子式： C₁₆₈H₂₅₀N₄₆O₄₁S₈ 

分子量：3828.00 Da 

外觀： White lyophilized solid 

可溶性：water and saline buffer 

CAS 號：484598-36-9 

來源： Synthetic  

純度：> 95 %

產(chǎn)品信息