ApexBio是生物研究用肽和實(shí)驗(yàn)室試劑的主要供應(yīng)商。我們在細(xì)胞凋亡,，表觀遺傳學(xué),，癌癥生物學(xué)等研究領(lǐng)域擁有廣泛的產(chǎn)品線。Apexbio還提供定制服務(wù),，包括肽合成,，抗體生產(chǎn)和分析開發(fā)。

我們的焦點(diǎn)

我們致力于通過提供多肽和生物分析試劑來滿足研究界的需求,，主要關(guān)注細(xì)胞凋亡和表觀遺傳學(xué),。

產(chǎn)品質(zhì)量

認(rèn)識到科學(xué)家工具與研究成功之間存在著千絲萬縷的聯(lián)系，ApexBio對產(chǎn)品的質(zhì)量給予了為謹(jǐn)慎的關(guān)注,。所有產(chǎn)品均按照嚴(yán)格的指導(dǎo)原則制造,，并附有分析證書，HPLC,，質(zhì)譜和HMNR數(shù)據(jù),。

技術(shù)支持

ApexBio的生物學(xué)家和化學(xué)家為我們的客戶提供廣泛的技術(shù)支持以使用這些產(chǎn)品。您可以期待我們的支持人員回答您的訂單和技術(shù)咨詢,，提供個性化和周到的服務(wù),。

窗體頂端

Catalog No.A4524

窗體底端

化學(xué)性質(zhì)

卡號 491-36-1

化學(xué)名稱 1H - 喹唑啉-4-酮

Canonical SMILES C1 = CC = C2C（= C1）C（= O）N = CN2

式 C 8 H 6 N 2 O. M.Wt 146.15

可溶性 > DMSO中> 55.6mg / mL 存儲 在室溫下干燥

運(yùn)輸條件 評估樣品解決方案：裝有藍(lán)色冰。所有其他可用尺寸：根據(jù)要求提供RT或藍(lán)冰

一般提示 為了獲得更高的溶解度,，請?jiān)?7℃下加熱管并在超聲波浴中搖動一段時(shí)間,。庫存溶液可在-20℃以下儲存數(shù)月。

背景

聚（ADP-核糖）聚合酶抑制劑（PARP）（IC50 =9.5μM）; 顯示對NAD +的混合抑制,。保護(hù)免受缺血再灌注誘導(dǎo)的ROS產(chǎn)生,，以及隨后的大鼠心臟線粒體和細(xì)胞損傷。體內(nèi)LPS誘導(dǎo)的內(nèi)毒素小鼠的抗炎作用; 減少NF-κB和AP-1活化,。

1. Cat.No                 .Product                                      NameInformation
2. A8181                   (-)-JQ1BET                               bromodomain inhibitor
3. B7679                 (R)-(+)-Etomoxir sodium salt            carnitine palmitoyltransferase I (CPT1) inhibitor
4. B7718               (R)-PFI 2 hydrochloride                     SETD7 histone lysine methyltransferase inhibitor
5. C4834                   (S)-PFI-2 (hydrochloride)             Negative control of (R)-PFI 2 hydrochloride
6. A4510               1,2,3,4,5,6-HexabromocyclohexaneJ          AK2 tyrosine kinase inhibitor
7. C4119              2',3',5'-triacetyl-5-Azacytidine   prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
8. B5972               2,4-Pyridinedicarboxylic Acid                 Histone LSD inhibitor
9. C4445                      2-D08                               Sumoylation inhibitor
10. B5969                2-hexyl-4-Pentynoic Acid                 Potent and robust HDACs inhibitor
11. A4188                  2-Methoxyestradiol (2-MeOE2)        Apoptotic, antiproliferative and antiangiogenic agen

1. A8182         3-Deazaneplanocin A (DZNep) hydrochloride      SAHH and ENZ2 inhibitor
2. A1905        3-Deazaneplanocin,DZNep             S-adenosylhomocysteine and EZH2 inhibitor
3. C3552        4'-bromo-Resveratrol                        Sirt1 and Sirt3 inhibitor
4. A4524         4-HQN                                       PARP inhibitor
5. C4018         4-iodo-SAHA         class I and class II histone deacetylase (HDAC) inhibitor
6. B4106       4SC-202                                  Class I HDAC inhibitor
7. C3505       5-(N,N-dimethyl)-Amiloride (hydrochloride)      NHE1, NHE2, and NHE3 inhibitor
8. A1907         5-Azacytidine                           DNA methyltransferase inhibitor.
9. B4947        A 366                      G9a/GLP histone lysine methyltransferase inhibitor
10. A4160        A-966492                                PARP-1/-2 inhibitor, highly potent

1. B1182           ABC294640                           Sphingosine kinase 2 inhibitor,selective and competitive
2. A3002         ABT-888 (Veliparib)                                      Potent PARP inhibitor
3. B5936           ACY-241                                Selective and orally active HDAC6 inhibitor
4. B6120          Adox                                          indirect methyltransferase inhibitor
5. A4158         AG-14361                                     Potent PARP1 inhibitor
6. B7323            AGK 2                                        SIRT2 inhibitor, potent and selective
7. C5709               AGK7                                     cell-permeable, selective inhibitor of SIRT2
8. B4713              AK-7                                   selective and brain-permeable SIRT2 inhibitor
9. A4542            Alexidine dihydrochloride                                PTPMT1 inhibitor
10. A4119               AMG-900                                           Aurora kinase inhibitor

上海起發(fā)實(shí)驗(yàn)試劑有限公司是實(shí)驗(yàn)試劑一站式采購服務(wù)商

1：強(qiáng)大的進(jìn)口輻射能力,，血清、抗體,、耗材,、大部分限制進(jìn)口品等。

2：產(chǎn)品種類齊全,，經(jīng)營超過700多品牌,，基本涵蓋所有生物實(shí)驗(yàn)試劑耗材。

3：提供加急服務(wù),，貨品一般1-2周到貨,。

4：富有競爭力的價(jià)格優(yōu)勢,，絕大部分價(jià)格有優(yōu)勢。

5：多年積累良好的信譽(yù),，大部分客戶提供貨到付款服務(wù),。客戶包括清華,、北大,、交大、復(fù)旦,、中山等100多所高校,，ROCHE，阿斯利康,、國藥,、fisher等知藥企。

6：我們還是Santa,Advanced Biotechnologies Inc,Athens Research & Technology,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, Genebridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,omicronbio, Polysciences,prospecbi, QA-BIO,quickzyme,RESEARCH DIETS,INC,sterlitech,；sysy,TriLink BioTechnologies,Inc,；worthington-biochem,zyagen等幾十家國外公司授權(quán)代理。

7：我們還是invitrogen,qiagen,MiraiBioam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知*批發(fā),，歡迎合作,。