S80128
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- 公司名稱 上海源葉生物科技有限公司
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- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2025/5/16 7:43:43
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- 產(chǎn)品描述： Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
- 靶點： Potassium Channel
- 體內(nèi)研究： Dofetilide (100 mg/kg, i.v.) does not suppress automaticity arrhythmias induced by two-stage coronary ligation and epinephrine or the coronary ligation and reperfusion arrhythmias, but suppresses the reentry arrhythmia induced by PES in dogs with old myocardial infarction (MI). Dofetilide also shows antiarrhythmic effect in some dogs with digitalis arrhythmia. Dofetilide increases QT interval and shows negative chronotropic effect like that of other class III drugs, but is different in antiarrhythmic profiles from those of other class III agents such as D-sotalol, E-4031, and MS-551 in that it does not prevent the occurrence of ventricular fibrillation (VF) immediately after coronary reperfusion and has some antiarrhythmic effects on digitalis arrhythmia. Dofetilide causes increased resorptions and the same stage-dependent malformations in Sprague-Dawley rats.
- 參考文獻：
1. Webster WS, et al. Teratology, 1996, 53(3), 168-175. 2. Bauer A, et al. J Cardiovasc Pharmacol, 2002, 39(3), 460-467. 3. Kiehn J, et al. Circulation, 1996, 94(10), 2572-2579. 4. Kiehn J, et al. J Cardiovasc Pharmacol, 1994, 24(4), 566-572. 5. Chen J, et al. J Cardiovasc Pharmacol, 1996, 28(4), 576-584.
- 溶解度： Soluble in DMSO
- 保存條件： Store in original container in a cool dark place.
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.265 ml 11.323 ml 22.647 ml 5 mM 0.453 ml 2.265 ml 4.529 ml 10 mM 0.226 ml 1.132 ml 2.265 ml 50 mM 0.045 ml 0.226 ml 0.453 ml
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