S80122
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- 公司名稱 上海源葉生物科技有限公司
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- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2025/5/16 7:36:39
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- 產(chǎn)品描述： SNS-314 mesylate is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively
- 靶點(diǎn)： Aurora A:9 nM (IC50);Aurora B:31 nM (IC50);Aurora C:6 nM (IC50)
- 體內(nèi)研究： In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off
- 參考文獻(xiàn)：
1. Oslob JD, et al. Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4. 2. Arbitrario JP, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17.
- 溶解度： DMSO : 150 mg/mL (284.61 mM; Need ultrasonic)
- 保存條件： -20℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 1.897 ml 9.487 ml 18.974 ml 5 mM 0.379 ml 1.897 ml 3.795 ml 10 mM 0.19 ml 0.949 ml 1.897 ml 50 mM 0.038 ml 0.19 ml 0.379 ml
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