OVA 257-264
| 參考價(jià) | ￥ 1200 |
| 訂貨量 | ≥1 件 |
- 公司名稱(chēng) 深圳欣博盛生物科技有限公司
- 品牌 Invivogen
- 型號(hào)
- 產(chǎn)地 法國(guó)
- 廠商性質(zhì) 代理商
- 更新時(shí)間 2022/1/28 17:07:14
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| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 1 mg |
|---|---|---|---|
| 貨號(hào) | vac-sin | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
| 主要用途 | 科研 |
wo OVA peptide standards for ELISPOT
InvivoGen provides two standard OVA peptides for detection use (ELISPOT):
OVA 257-264 is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb [1].
It has been demonstrated that OVA 257-264 peptides can be used to detect a strong CD8+ cytolytic T cell response [2].
OVA 323-339 encompasses an allergenic and antigenic epitope of the ovalbumin protein [3]. OVA 323-339 peptide binds to I-A(d) MHC class II protein [4].
OVA 323-339 has been used extensively to study the nature of class II MHC-peptide binding and T-cell activation [5-6].
References:
1. R?tzschke O. et al., 1991. Exact prediction of a natural T cell epitope. Eur J Immunol.21(11):2891-4.
2. Lipford GB. et al., 1993. Primary in vivo responses to ovalbumin. Probing the predictive value of the Kb binding motif. J Immunol. 150(4):1212-1222.
3. McFarland BJ et al. 1999. Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers. Biochemistry. 38(50):16663-70.
4. Johnsen G & Elsayed S. 1990. Antigenic and allergenic determinants of ovalbumin-111. MHC Ia-binding peptide (OA 323-339) interacts with human and rabbit specific antibodies. Mol Immunol. 27821-7.
5. Bickert T. et al. 2007. Murine polyomavirus-like particles induce maturation of bone marrow derived dendritic cells and proliferation of T cells. Med Microbiol Immunol 196:31–9.
6. Szymczak-Workman AL.et al. 2009. Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress. J Immunol 1:182.
Specifications
OVA 257-264
Description: H-2Kb-restricted OVA MHC class I epitope
Sequence: SIINFEKL
MW: 963.2
Solubility: 1 mg/ml in water
OVA 323-339
Description: I-Ad-restricted OVA MHC class II epitope
Sequence: ISQAVHAAHAEINEAGR
MW: 1773.9
Solubility: 1 mg/ml in water
Contents
1 mg OVA 257-264 or OVA 323-339 provided lyophilized.
Products are shipped at room temperature.
Stored at -20°C.
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