CT99021 CHIR-99021
- 公司名稱 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型號 CT99021
- 產(chǎn)地
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2020/1/7 9:02:23
- 訪問次數(shù) 858
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MedChemExpress (MCE) 專注于為科學(xué)家提供高品質(zhì)的生物活性小分子化合物，化合物庫及各類試劑盒,，總部位于美國新澤西,。
• MedChemExpress (MCE) 產(chǎn)品作用于 20 多個熱門信號通路及研究領(lǐng)域的300多個細(xì)分靶點(diǎn)，擁有 10000 特異性抑制劑,、激動劑,，以及 50 活性化合物篩選庫；
• 我們堅持對所有產(chǎn)品進(jìn)行嚴(yán)格質(zhì)檢,，確保產(chǎn)品的高品質(zhì)和高純度,；
• MedChemExpress (MCE) 產(chǎn)品已被數(shù)萬名科學(xué)家信賴，并被大量top文獻(xiàn)和*引用,；
• 我們擁有專業(yè)的技術(shù)團(tuán)隊追蹤前沿科研進(jìn)展,，不斷豐富各個靶點(diǎn)的特異性產(chǎn)品，堅持做 “您身邊的抑制劑大師”,；
• MedChemExpress (MCE) 與眾多藥企和科研機(jī)構(gòu)保持深度合作,；
• 大量產(chǎn)品有中國庫存，工作日 16:00 前訂單確保當(dāng)日發(fā)貨,，次日送達(dá),。
MCE 中國站：www.MedChemExpress.cn
Hotline: 400-820-3792
Tel: 021-58955995
Email: [email protected]
Tech Support: 021-58950656
抑制劑，調(diào)節(jié)劑,，API,，天然產(chǎn)物，各種類型化合物庫
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL,；2 mg,；5 mg |
|---|---|---|---|
| 貨號 | HY-10182 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
CHIR-99021
產(chǎn)品活性：CHIR-99021是 GSK-3α/β 抑制劑， IC50 分別為 10 nM,，6.7 nM,。 抑制 GSK-3α/β 比同源物 CDC2 和 ERK2 高 500 倍。
研究領(lǐng)域：PI3K/Akt/mTOR | Stem Cell/Wnt | Autophagy
作用靶點(diǎn)：GSK-3 | Autophagy
In Vitro: CHIR 99021inhibits human GSK-3β with Ki values of 9.8 nM. CHIR 99021 is a small organic molecule that inhibits GSK3α and GSK3β by competing for their ATP-binding sites.In vitro kinase assays reveal that CHIR 99021 specifically inhibits GSK3β (IC50=~5 nM) and GSK3α (IC50=~10 nM), with little effect on other kinases. In the presence of CHIR-99021 the viability of the ES-D3 cells is reduced by 24.7% at 2.5 μM, 56.3% at 5 μM, 61.9% at 7.5 μM and 69.2% at 10 μM CHIR-99021 with an IC50 of 4.9 μM.
In Vivo: In ZDF rats, a single oral dose of CHIR 99021 (16 mg/kg or 48 mg/kg) rapidly lowers plasma glucose, with a maximal reduction of nearly 150 mg/dl 3-4 h after administration. CHIR99021 (2 mg/kg) given once, 4 h before irradiation, significantly improves survival after 14.5 Gy abdominal irradiation (ABI). CHIR99021 treatment significantly blocks crypt apoptosis and accumulation of p-H2AX+ cells, and improves crypt regeneration and villus height. CHIR99021 treatment increases Lgr5+ cell survival by blocking apoptosis, and effectively prevents the reduction of Olfm4, Lgr5 and CD44 as early as 4 h.
相關(guān)產(chǎn)品：Kinase Inhibitor Library | Stem Cell Signaling Compound Library | PI3K/Akt/mTOR Compound Library | Anti-Cancer Compound Library | Bioactive Compound Library Plus | Autophagy Compound Library | Wnt/Hedgehog/Notch Compound Library | SB 216763 | TWS119 | LY2090314 | GSK 3 Inhibitor IX | Tideglusib | Kenpaullone | AR-A014418 | CHIR-99021 trihydrochloride | AZD2858 | AZD1080 | Indirubin-3'-monoxime | RGB-286638 free base | SB 415286 | Bikinin | TDZD-8 | CHIR-98014 | IM-12 | CP21R7 | BIO-acetoxime | EHT 5372 | GSK-3 inhibitor 1 | 5-Iodo-indirubin-3'-monoxime | GSK-3β inhibitor 1 | Indirubin-3'-monoxime-5-sulphonic acid | Indirubin-5-sulfonate
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