sc SC-560
- 公司名稱 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型號(hào) sc
- 產(chǎn)地
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2019/7/11 18:12:02
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MedChemExpress (MCE) 專注于為科學(xué)家提供高品質(zhì)的生物活性小分子化合物，化合物庫(kù)及各類試劑盒,，總部位于美國(guó)新澤西,。
• MedChemExpress (MCE) 產(chǎn)品作用于 20 多個(gè)熱門信號(hào)通路及研究領(lǐng)域的300多個(gè)細(xì)分靶點(diǎn),，擁有 10000 特異性抑制劑、激動(dòng)劑,，以及 50 活性化合物篩選庫(kù),；
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• 我們擁有專業(yè)的技術(shù)團(tuán)隊(duì)追蹤前沿科研進(jìn)展,，不斷豐富各個(gè)靶點(diǎn)的特異性產(chǎn)品,，堅(jiān)持做 “您身邊的抑制劑大師”；
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抑制劑,，調(diào)節(jié)劑，API,，天然產(chǎn)物,，各種類型化合物庫(kù)
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL；5 mg,；10 mg |
|---|---|---|---|
| 貨號(hào) | HY-59105 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
SC-560
產(chǎn)品活性：SC-560是有效,，選擇性的 COX-1 抑制劑，IC50 值為9 nM,。
研究領(lǐng)域：Immunology/Inflammation
作用靶點(diǎn)：COX
In Vitro: Preincubation of COX-1 with SC-560 inhibits the conversion of arachidonic acid to PGE2 in a concentration-dependent manner. The IC50 of SC-560 for COX-2 is 6.3 μM, nearly 1,000-fold higher than with COX-1. SC-560 shows a dose and time dependent inhibitory effect on HCC cell growth. SC-560 also inhibits colony formation in soft agar and induces apoptosis in HCC cells in a dose-dependent manner. Moreover, SC-560 decreases the levels of the anti-apoptotic proteins survivin and XIAP and activates caspase 3 and 7 in a dose and time dependent fashion.
In Vivo: Oral dosing with either 10 or 30 mg/kg SC-560 1 hour before assay completely inhibits ionophore-stimulated TxB2production, indicating that SC-560 is orally bioavailable and inhibits COX-1 in vivo. SC-560 extensively distributes into rat tissues, and has a CL approaching hepatic plasma flow. The drug displays low less than 15% and formulation dependent bioavailability after oral administration and demonstrates kidney toxicity.
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