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Transforming Growth Factor Beta 2 （TGF-β2） is a member of the TGF-β superfamily, which plays a critical role in various biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. TGF-β2 is synthesized as a latent complex, consisting of a mature peptide homodimer, a latency-associated peptide （LAP）, and latent TGF-β binding proteins （LTBPs）. This latent form must be activated to exert its biological effects.
TGF-β2 is involved in multiple physiological and pathological processes. It promotes tissue repair and wound healing but can also contribute to fibrosis and tumor progression. In cancer, TGF-β2 is known to inhibit immune surveillance, facilitating tumor growth and metastasis. Additionally, TGF-β2 signaling is implicated in various diseases, including systemic sclerosis, fibrosis, and Loeys-Dietz syndrome.