日韩av大片在线观看欧美成人不卡|午夜先锋看片|中国女人18毛片水多|免费xx高潮喷水|国产大片美女av|丰满老熟妇好大bbbbbbbbbbb|人妻上司四区|japanese人妻少妇乱中文|少妇做爰喷水高潮受不了|美女人妻被颜射的视频,亚洲国产精品久久艾草一,俄罗斯6一一11萝裸体自慰,午夜三级理论在线观看无码

Urokinase plasminogen activator surface receptor （U-PAR）, also known as PLAUR, Monocyte activation antigen Mo3, or CD87, is a key player in cellular processes involving migration and tissue remodeling. It binds to urokinase-type plasminogen activator （uPA）, which converts plasminogen to plasmin, a serine protease essential for normal and pathological cell migration and tissue destruction. uPA is initially released as a single-chain pro-enzyme （scuPA） with low activity and is activated to a two-chain form （tcuPA） by plasmin and other proteinases. Both forms of uPA bind to uPAR, localizing uPA's proteolytic activity and enhancing its enzymatic activity.The uPA/uPAR interaction initiates signal transduction, activating protein tyrosine kinases, influencing gene expression, and promoting cell adhesion and chemotaxis. uPAR can also modulate integrin function, suppressing normal adhesion while enhancing vitronectin binding through its high-affinity site. This interaction is significant in various inflammatory diseases, including cancer, cardiovascular diseases, chronic kidney diseases, and diabetes, making uPAR a potential biomarker for these conditions