目錄:杭州斯達(dá)特生物科技有限公司>>蛋白>>藥物靶點(diǎn)和Fc受體>> UA011116LY75/CD205 His Tag Protein, Human
參考價(jià) | ¥ 1280 |
參考價(jià) | ¥ 1280 |
更新時(shí)間:2025-06-17 10:08:48瀏覽次數(shù):18評(píng)價(jià)
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Lymphocyte antigen 75 (Ly75), also known as CD205, CLEC13B, GP200-MR6, and DEC-205, is a type I transmembrane protein predominantly expressed on dendritic cells and thymic epithelial cells. Ly75 functions as an endocytic receptor for antigens. MEN1309/OBT076, the first antibody drug targeting CD205, has demonstrated strong preclinical anti-tumor activity in lymphoma models.
Upon verification as a monotherapy in vivo, the antibody-drug conjugate (ADC) has been found to have a synergistic effect when combined with the BCL2 inhibitor Venetoclax and the anti-CD20 monoclonal antibody rituximab.
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