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CD73, also known as ecto-5′-nucleotidase （ecto-5′-NT, EC 3.1.3.5） is a glycosylphosphatidyl inositol （GPI）-anchored cell surface protein that is encoded by NT5E gene. CD73 is widely expressed on different tissues [PubMed: 9553767, PubMed: 18404475] and cell types including, but not limited to the subsets of T cells and B cells [PubMed: 2550543], endothelial cells [PubMed: 9015312, PubMed: 15358667] and epithelial cells [PubMed: 9169488].