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T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene. The TCL1 locus on human chromosome 14q32.1 is activated in T-cell leukemias by translocations and inversions that juxtapose it to regulatory elements of T-cell receptor genes. TCL1A has been shown to interact with AKT1 and AKT2. Protein expression in immature T and B lymphoid cells and overexpression of TCL1 is considered critical in the oncogenetic transformation.