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Caldesmon is a binding protein of smooth actin and calmodulin, a cytoskeleton-associated protein present in thin filaments （smooth and striated muscles） that regulates the interaction of actin and myosin. It is available in low molecular weight （l-Caldesmon） and high molecular weight （h-Caldesmon）. The latter is thought to be present only in visceral and vascular smooth muscle and myoepithelium. Caldesmon is commonly used in the diagnosis of smooth muscle differentiation tumors.