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Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined. Keratin 14 is also known as cytokeratin-14 （CK-14） or keratin-14 （KRT14）. In humans it is encoded by the KRT14 gene. Keratin 14 is expressed in mitotically active basal layer cells, along with its partner keratin 5 （K5）, and their expression is down-regulated as cells differentiate. Keratin 14 has been studied as a prognostic marker in breast cancer. Keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and has been reported useful in the identification of squamous cell carcinomas.