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CD25, also known as IL2RA, is the alpha chain of the high-affinity interleukin-2 receptor, which is a heterotrimeric complex that also includes beta （IL2RB） and the common gamma chain （IL2RG）. This receptor interacts with interleukin-2, a cytokine crucial for immune homeostasis. CD25 is typically expressed on activated T lymphocytes and plays a significant role in their proliferation and function. It is also found on certain B cells, where its expression can be upregulated by specific Toll-like receptor ligands. In addition to its role in the immune system, CD25 has potential as a therapeutic target in cancer treatment due to its expression on various tumor cells.