目錄:杭州斯達(dá)特生物科技有限公司>>抗體/抗原>>流式抗體>> S0B5253Biotin Mouse Anti-Human TCR γ/δ Antibody (S-R637)
參考價(jià) | ¥ 1000 |
參考價(jià) | ¥ 1000 |
更新時(shí)間:2025-06-11 09:27:27瀏覽次數(shù):19評(píng)價(jià)
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The TCR γ/δ protein is a distinctive T-cell receptor (TCR) expressed on the surface of γδ T cells, composed of a γ chain and a δ chain linked by disulfide bonds to form a heterodimer, belonging to the immunoglobulin superfamily. Unlike the conventional αβ TCR, the γδ TCR can directly recognize a broad range of antigens (e.g., phosphorylated metabolites, lipids, stress proteins) without requiring MHC presentation, granting it broader antigen specificity. Its variable (V) region diversity arises from V, (D), and J gene segment rearrangements, though it exhibits less diversity than the αβ TCR. γδ T cells are primarily found in mucosal tissues, skin, and the gut, playing crucial roles in early immune defense, tumor surveillance, and tissue repair. They can rapidly secrete cytokines (e.g., IFN-γ, IL-17) or exert cytotoxic effects, serving as key effector cells bridging innate and adaptive immunity.
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