日韩av大片在线观看欧美成人不卡|午夜先锋看片|中国女人18毛片水多|免费xx高潮喷水|国产大片美女av|丰满老熟妇好大bbbbbbbbbbb|人妻上司四区|japanese人妻少妇乱中文|少妇做爰喷水高潮受不了|美女人妻被颜射的视频,亚洲国产精品久久艾草一,俄罗斯6一一11萝裸体自慰,午夜三级理论在线观看无码

CD272, also known as B- and T-lymphocyte attenuator （BTLA）, is an inhibitory receptor belonging to the CD28 immunoglobulin superfamily. It is encoded by the BTLA gene and primarily expressed on B cells, T cells, macrophages, and dendritic cells. BTLA plays a crucial role in regulating immune responses by acting as a negative regulator of antigen receptor signaling. Its ligand is HVEM （herpesvirus entry mediator, also known as CD270）, and their interaction inhibits T cell and B cell activation, proliferation, and cytokine production. Structurally, BTLA is similar to other immune checkpoint proteins like PD-1 and CTLA-4, containing an extracellular IgV-like domain and intracellular immunoreceptor tyrosine-based inhibitory motifs （ITIMs） that mediate its inhibitory functions. BTLA's signaling involves the recruitment of tyrosine phosphatases SHP-1 and SHP-2, which dampen immune activation. Due to its role in immune regulation, the BTLA-HVEM axis is considered a promising target for cancer immunotherapy.