目錄:亞科因（武漢）生物技術(shù)有限公司>>細胞因子及蛋白>>細胞因子>> Mouse GM-CSF protein重組小鼠粒細胞-巨噬細胞集落刺激因子（GM-CSF）2
| 產(chǎn)品英文名稱 | Mouse GM-CSF protein |
| 產(chǎn)品中文名稱 | 重組小鼠粒細胞-巨噬細胞集落刺激因子（GM-CSF） |
| 別名 | CSF; CSF2; CSF-2; GMCSF; GM-CSF;colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; GMCSF, granulocyte-macrophage colony stimulating factor; molgramostin; Sargramostim, MGC131935; MGC138897; Molgramostim; |
| 分子 | GM-CSF |
| 標簽 | 無標簽 |
| 種屬 | 小鼠 |
| 序列 | Amino acid sequence derived from Mouse GM-CSF protein isoform (P01587，Met1-Lys141) was expressed. |
| 活性 | 通過其在FDC-P1細胞中誘導(dǎo)增殖的能力在0.009-2.5 ng/mL的線性范圍內(nèi)測量,。 |
| 蛋白長度 | 重組小鼠GM-CSF蛋白由128個氨基酸組成,，預(yù)測分子量為14.6 kDa。 在還原條件下,，SDS-PAGE中小鼠GM-CSF蛋白的表觀分子量約為15-25 kDa,。 |
| 純度 | ≥ 90 % ，使用SDS-PAGE檢測 |
| 特點&優(yōu)勢 | 采用 LAL 法檢測,，每 1 μg 蛋白質(zhì)中的 EU 含量小于 1.0,。 |
| 產(chǎn)品形式 | 凍干粉,，凍干緩沖液為無菌的 PBS，pH 7.4,。 |
| 基因ID | 12981 |
| 蛋白序列鏈接 | /uniprot/P01587 |
| 使用中注意事項 | 開蓋使用前,，請先離心。本產(chǎn)品為凍干粉,，推薦用該產(chǎn)品配套的Reconstitution Buffer進行復(fù)溶,，且濃度不低于100 µg/mL?？蛻艨筛鶕?jù)后續(xù)的實驗需求,，進行進一步的稀釋。 |
| 保存建議 | 本產(chǎn)品為凍干粉形式,，建議：將凍干粉的重組小鼠粒細胞-巨噬細胞集落刺激因子（GM-CSF）產(chǎn)品保存于-20℃以下的干燥環(huán)境中,。本產(chǎn)品溶解之后，可在4℃保存2-7天,，長期使用請置于-20℃以下,。為長期保存，推薦添加載體蛋白（0.1% HSA或者BSA）,，并酌情分裝保存,，避免反復(fù)凍融。 |
| 運輸條件 | 常溫運輸 |
| 警告 | 本文列出的產(chǎn)品僅供研究使用,，不適用于人類或臨床診斷,。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何或許可證,。對于使用本產(chǎn)品可能發(fā)生的侵權(quán)或其他違規(guī)行為,，我們不承擔任何責任。 |
| 背景 | The granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. Although GM-CSF is produced locally, it can act in a paracrine fashion to recruit circulating neutrophils, monocytes and lymphocytes to enhance their functions in host defense. GM-CSF was initially classified as a hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) and granulocyte CSF (G-CSF), the majority of myeloid cells do not require GM-CSF for steady-state myelopoiesis. Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. Even though lymphocytes are in all likelihood the instigators of chronic inflammatory disease, GM-CSF-activated phagocytes are well equipped to cause tissue damage. |
Fig.SDS-PAGE analysis of Mouse GM-CSF protei.
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