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Indirubin

MCE 國際站：Indirubin

品牌：MedChemExpress (MCE)

貨號(hào)：HY-N0117

CAS：479-41-4

中文名稱：靛玉紅

Synonyms：靛玉紅; Couroupitine B; Indigo red; Indigopurpurin

純度：98.74%

存儲(chǔ)條件：粉末 -20°C 3 年 4°C 2 年 溶劑中 -80°C 6 個(gè)月 -20°C 1 個(gè)月

運(yùn)輸條件：美國大陸的室溫,；其他地方可能有所不同,。

產(chǎn)品活性：Indirubin (Couroupitine B) 是一種雙吲哚生物堿,，對(duì)慢性粒細(xì)胞白血病具有顯著的抗癌活性。

生物活性：Indirubin (Couroupitine B) 是一種雙吲哚生物堿,，對(duì)慢性粒細(xì)胞白血病具有顯著的抗癌活性^[1][2],。 體外靛玉紅 (Couroupitine B) 顯著抑制 Td-EC 增殖、遷移,、侵襲和血管生成^[1],。 體內(nèi)：靛玉紅（Couroupitine B）（12.5 mg/kg，25 mg/kg,；腹膜內(nèi)注射,；每天一次，持續(xù) 14 天）可減少呈劑量依賴性^[3],。

體外：靛玉紅（Couroupitine B）顯著抑制Td-EC增殖,、遷移、侵襲和血管生成[1],。MCE尚未獨(dú)立證實(shí)這些方法的準(zhǔn)確性,。它們僅供參考。

體內(nèi)：靛玉紅（Couroupitine B）（12.5 mg/kg,、25 mg/kg,，腹腔注射，每天一次,，連續(xù)14天）可劑量依賴性地減輕病理改變[3],。MCE尚未獨(dú)立證實(shí)這些方法的準(zhǔn)確性,。僅供參考。

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參考文獻(xiàn)：

[1]. Kim MH, et al. Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. J Ethnopharmacol. 2013 Jan 9;145(1):214-9.
[2]. Hsieh WL, et al. Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes. J Dermatol Sci. 2012 Aug;67(2):140-6.
[3]. Zhang X, et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer. 2011 Nov 15;129(10):2502-11.
[4]. Alex D, et al. Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model. J Ethnopharmacol. 2010 Sep 15;131(2):242-7.
[5]. Li, Zhuohong, et al. Indirubin inhibits cell proliferation, migration, invasion and angiogenesis in tumor-derived endothelial cells. OncoTargets and therapy vol. 11 2937-2944. 18 May. 2018.
[6]. Mohan, Lakshmi, et al. Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine. Biomed Pharmacother. 2018 Sep;105:506-517.
[7]. Wang, Qi, et al. Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation. Biomedicine pharmacotherapy vol. 131 (2020): 110715.