MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務,。

2-Hydroxybutyric acid

MCE 國際站：2-Hydroxybutyric acid

品牌：MedChemExpress (MCE)

CAS：600-15-7

純度：≥98.0%

貨號：HY-113381

中文名稱：2-羥基丁酸

Synonyms：2-羥基丁酸; α-Hydroxybutyric acid

存儲條件：純品 -20°C 3 年 4°C 2 年 溶劑中 -80°C 6 個月 -20°C 1 個月

運輸條件：美國大陸的室溫,；其他地方可能有所不同。

產(chǎn)品活性：2-Hydroxybutyric acid (α-Hydroxybutyric acid) 由 2-Aminobutyric acid 轉(zhuǎn)化而來,，2-oxobutyric acid 為中間代謝物,。2-Hydroxybutyric acid 是 2 型糖尿病和先兆子癇的潛在生物標志物。2-Hydroxybutyric acid 可預防 acetaminophen (AP) 引起的肝損傷,。

體外：2-Hydroxybutyric acid 胰島素抵抗的副產(chǎn)物,，會導致胰島素信號傳導受損和線粒體超載[2]。2-Hydroxybutyric acid (0-40 mM) 可增強 BRL3A,、AML12 和小鼠原代肝細胞的細胞活力并降低 AP 誘導的細胞毒性[3],。MCE尚未獨立證實這些方法的準確性。僅供參考,。

體內(nèi)：2-Hydroxybutyric acid (250 mg/kg/天,，腹腔注射，三天) 預防 C57 小鼠體內(nèi) AP 誘導的肝損傷,，調(diào)節(jié)參與炎癥反應,、氧化應激、細胞增殖和 DNA 損傷的基因表達,，使其正?；痆3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50 & Target：Human Endogenous Metabolite

銷售產(chǎn)品：Cedazuridine  | γ-Glutamylhistidine  | Batefenterol  | Famotidine  | Leucomethylene blue (mesylate)  | Clomethiazole  | Biliverdin Reductase A/BLVRA, Human (C-His)  | Itraconazole-d5  | Acevaltrate  | Deoxynyboquinone

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

參考文獻：

[1]. Landaas S, et al. The formation of 2-hydroxybutyric acid in experimental animals. Clin Chim Acta. 1975 Jan 6;58(1):23-32.[2]. Shantavasinkul PC, et al., Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid. Surg Obes Relat Dis. 2018 Aug;14(8):1126-1132.[3]. Zheng N, et al., Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid. J Pharm Anal. 2020 Dec;10(6):560-570.[4]. Wang F, et al., Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia. Open Life Sci. 2023 Feb 28;18(1):20220572.