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Blinatumomab | 貝林妥歐單抗

MCE 國際站：Blinatumomab

品牌：MedChemExpress (MCE)

CAS：853426-35-4

貨號：HY-P9963

中文名稱：貝林妥歐單抗,；博納吐單抗

Synonyms：貝林妥歐單抗; Anatumomab

存儲條件：請按照分析證書中建議的條件儲存產(chǎn)品,。

運輸條件：使用干冰運輸,。

產(chǎn)品活性：Blinatumomab (Anatumomab) 是一種雙特異性單克隆抗體，有兩個結(jié)合位點,，分別是 T 細胞表面的 CD3E 和 B 細胞表面的 CD19,。Blinatumomab 可用于急性淋巴細胞白血病的研究。

體內(nèi)：Blinatumomab (0.01-1 μg, 靜脈注射, 每日一次持續(xù) 5 天) 在白血病非肥胖糖尿病SCID小鼠模型中,，以劑量依賴的方式延長了小鼠的生存時間[2],。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

種屬：Mouse

同型：(scFv-kappa-heavy)-(scFv-heavy-kappa)

銷售產(chǎn)品：FGFR1/DDR2 inhibitor 1  | LEI-401  | DY131  | Monotropein  | trans-Cinnamaldehyde  | Aumitin  | Ozanimod (hydrochloride)  | 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)  | Ranolazine  | Isorhamnetin-3-O-neohespeidoside

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

參考文獻：

[1]. Kantarjian H, et, al. Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia. N Engl J Med. 2017 Mar 2;376(9):836-847. [2]. Dreier T, et al. T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3- bispecific single-chain antibody construct. J Immunol. 2003 Apr 15;170(8):4397-402.[3]. Hoffman LM, et al. Blinatumomab, a Bi-Specific Anti-CD19/CD3 BiTE(®) Antibody for the Treatment of Acute Lymphoblastic Leukemia: Perspectives and Current Pediatric Applications. Front Oncol. 2014 Mar 31;4:63. [4]. Zhang R, et al. The establishment and application of CD3E humanized mice in immunotherapy[J]. Experimental Animals, 2022, 71(4): 442-450.