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Delamanid

CAS No. : 681492-22-8

MCE 國際站：Delamanid

產(chǎn)品活性：Delamanid是一個用于耐多藥結(jié)核病的化合物,，也是新的分枝桿菌細胞壁合成抑制劑。

研究領(lǐng)域：Anti-infection

作用靶點：Bacterial  |  Antibiotic

In Vitro: Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex.
Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis.
Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration.

In Vivo: Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL.

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