MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù),。

IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His)

MCE 國際站：IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His)

IL-2R beta (CD122),，一種表達于 T 淋巴細胞上的 Ⅰ 型細胞因子受體，是 IL-2 的受體,。IL-2R beta 可介導(dǎo) T 細胞免疫反應(yīng),，如刺激 T 細胞增殖、激活淋巴因子激活的殺傷細胞,。IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His) 是一種由 HEK293 細胞產(chǎn)生的,、重組犬 IL-2R beta (217a.a, N30-P246), 其 C 末端帶有 His 標簽。

Synonyms: IL2RB; RP5-1170K4.6; CD122; P70-75

Species: Canine

Source: HEK293

Biological Activity: Measured by its ability to inhibit the IL-15-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED₅₀ for this effect is 0.4095 μg/mL in the presence of 4 ng/mL of recombinant human IL-15, corresponding to a specific activity is 2.44×10³ units/mg.

研究背景：IL-2R beta (CD122) is a type I cytokine receptor, and belongs to Type 4 subfamily. IL-2R beta is also a key component of the IL-15 receptor. IL-2R beta is broadly expressed in spleen, blood, and lymph node, such as B and T lymphocytes.
The sequence of amino acids in IL-2R beta differs in different species.
IL-2R beta cytoplasmic domain heterodimerizes with IL-2 and leads to the activation of signaling pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAP kinase, and the JAK-STAT pathways. IL-2R beta binds IL-2 with intermediate affinity. IL-2R beta mediates IL-2 internalization and signal transduction, such as cell proliferation or differentiation. IL-2R beta interacts with IL-2 and increases the proportion of CD4+ T lymphocytes. IL-2R stimulates T cell proliferation and activating lymphokine-activated killer cells.
IL-2R beta mediates T cell immune responses, and also mediates endocytosis, as well as transducing the mitogenic signals of IL-2.

蛋白編號：NP_001273780.1 (N30-P246)

基因 ID：403439

產(chǎn)品分類：細胞因子和生長因子  |  白細胞介素  |  白介素-2 受體  |  白介素-2 受體 beta  |  CD 抗原  |  NK 細胞 CD 蛋白  |  CD122/IL-2R beta

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-2 Receptor  |  IL-2R beta  |  CD Antigens  |  NK Cell CD Proteins  |  CD122/IL-2R beta

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*化合物庫,，我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物,；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領(lǐng),；
•   產(chǎn)品種類涵蓋各種重組蛋白,，多肽，常用試劑盒 ,，更有 PROTAC,、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā),、生命科學(xué)等科研項目,；
•   提供虛擬篩選，離子通道篩選,，代謝組學(xué)分析檢測分析,，藥物篩選等專業(yè)技術(shù)服務(wù),；
•   設(shè)有專業(yè)的實驗中心和嚴格的質(zhì)控、驗證體系,；
•   提供 LC/MS,、NMR、HPLC,、手性分析,、元素分析等各項質(zhì)檢報告，確保產(chǎn)品的高純度,、高品質(zhì),；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果,；
•   專業(yè)團隊跟蹤最新的制藥及生命科學(xué)研究進展,，為您提供*新新的活性化合物；
•   與世界各大制藥公司及著名科研機構(gòu)建立了長期的合作,。