MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào),，我們不為任何個人用途提供產(chǎn)品和服務(wù),。

O-304

CAS No. : 1261289-04-6

產(chǎn)品活性：O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications .

研究領(lǐng)域：Epigenetics  |  PI3K/Akt/mTOR

作用靶點(diǎn)：AMPK

In Vivo: O-304 increases glucose uptake in skeletal muscle, reduced β cell stress, and promoted β cell rest in diet-induced obese mice. O-304 reduces fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin.

相關(guān)產(chǎn)品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Anti-diabetic Compound Library  |  Oxygen Sensing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Lipid Metabolism Compound Library   |  Glucose Metabolism Compound Library  |  Pain-Related Compound Library  |  ZLN024  |  YLF-466D  |  Nepodin  |  AMPK activator 9  |  Metformin-d₆ (hydrochloride)  |  AMPK-IN-3  |  HTH-01-015  |  AMARA peptide TFA  |  LRRK2/NUAK1/TYK2-IN-1  |  AMPK-IN-1  |  AICAR  |  Metformin  |  BC1618  |  BAY-3827  |  Chamaejasmine  |  PF-06409577  |  Etilefrine  |  IM156  |  Narazaciclib  |  Flufenamic acid-d₄  |  PF-739  |  RSVA405  |  MARK4 inhibitor 1  |  Phenformin hydrochloride  |  MARK-IN-2  |  Danthron  |  Galegine hydrochloride  |  Dorsomorphin  |  Gomisin J  |  Palmitelaidic Acid

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點(diǎn)擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物,；
•   50,000 多種高選擇性抑制劑,、激動劑涉及各熱門信號通路及疾病領(lǐng),；
•   產(chǎn)品種類涵蓋各種重組蛋白,，多肽，常用試劑盒 ,，更有 PROTAC,、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā),、生命科學(xué)等科研項(xiàng)目,；
•   提供虛擬篩選，離子通道篩選,，代謝組學(xué)分析檢測分析,，藥物篩選等專業(yè)技術(shù)服務(wù)；
•   設(shè)有專業(yè)的實(shí)驗(yàn)中心和嚴(yán)格的質(zhì)控,、驗(yàn)證體系,；
•   提供 LC/MS、NMR,、HPLC,、手性分析,、元素分析等各項(xiàng)質(zhì)檢報(bào)告，確保產(chǎn)品的高純度,、高品質(zhì),；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實(shí)驗(yàn)驗(yàn)證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果,；
•   專業(yè)團(tuán)隊(duì)跟蹤最新的制藥及生命科學(xué)研究進(jìn)展,，為您提供*新的活性化合物；
•   與世界各大制藥公司及著名科研機(jī)構(gòu)建立了長期的合作,。