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Acoltremon

CAS No. : 68489-09-8

產(chǎn)品活性：Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research.

研究領(lǐng)域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶點(diǎn)：TRP Channel

In Vitro: Acoltremon (10 μM) shows TRPM8 agonism in tests on heterologously expressed TRP ion channels.
Acoltremon (1 or 10 μM; 0-250 s) shows highly potent and specific TRPM8 channel agonist in DRG neurons.

In Vivo: Acoltremon (intraperitoneal injection; 10 mg/kg; once) shows analgesic effect by selective TRPM8 activation in mice.

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