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PROTAC AR Degrader-4

CAS No. : 1351169-31-7

產(chǎn)品活性：PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).

研究領(lǐng)域：PROTAC  |  Vitamin D Related/Nuclear Receptor

作用靶點：SNIPERs  |  PROTACs  |  Androgen Receptor

In Vitro: Specific and Nongenetic IAPs-dependent Protein Erasers (SNIPERs) are bifunctional compounds which are designed by conjugating an IAPs-recognition structure with a target protein-recognition structure.
Targeting proteins for degradation involves three steps.
1, its two recognition structures allow SNIPER to form a complex linking IAPs, which have E3 ligase activity, with the target protein.
2, the target protein is polyubiquitinated by IAPs.
3, the polyubiquitinated protein is degraded by proteasome.

相關(guān)產(chǎn)品：SNIPER(ABL)-013  |  LC-2  |  ACBI2  |  Medroxyprogesterone acetate-d₃  |  iRucaparib-AP6  |  BSJ-04-132  |  Androgen receptor antagonist 4  |  PROTAC VEGFR-2 degrader-1  |  VPC-13789  |  SR-1114  |  Acetyl-ACTH (7-24) (human, bovine, rat)  |  PROTAC CRABP-II Degrader-3  |  PROTAC Sirt2 Degrader-1  |  CSRM617 hydrochloride  |  CRBN-6-5-5-VHL  |  PROTAC BRD2/BRD4 degrader-1  |  BSJ-03-204  |  Ar-V7-IN-1  |  Acetyl-ACTH (3-24) (human, bovine, rat)  |  JPS016  |  Cyproterone acetate-d₃  |  KB02-JQ1  |  TD-802  |  GTx-007  |  BSJ-03-123  |  PROTAC RIPK degrader-6  |  VZ185  |  PROTAC BRD9 Degrader-4  |  MS5033

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