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Bleomycin sulfate

CAS No. : 9041-93-4

產(chǎn)品活性：Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic.

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Anti-infection

作用靶點(diǎn)：DNA/RNA Synthesis  |  Antibiotic

結(jié)構(gòu)分類：抗生素  |  其他類  |  結(jié)構(gòu)分類

In Vitro: Bleomycin (BLM) sulfate is chosen as the best-studied micronucleus (MN) inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation.
The IC₅₀ value of Bleomycin sulfate for UT-SCC-19A cell line is 4.0±1.3 nM. UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin (BLM); IC₅₀ values are 14.2±2.8 nM and 13.0±1.1 nM, respectively.
Bleomycin sulfate (50, 100?μM; for 24, 48?h) induce pulmonary fibrosis in RLE-6TN cell (50?μM) and A549 cell (100?μM).

In Vivo: Bleomycin sulfate treatment (3.5-4.0?mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study.
Bleomycin sulfate (3.5-4.0?mg/kg;?intra-tracheal) produces a statistically significant increase in lung?hydroxyproline?levels, and also increases right caudal?lung lobe?mass.
Bleomycin sulfate (intratracheal instillation; 5.0?mg/kg/day) induces pulmonary fibrosis in eighty 8-week-old male BALB/c mice with weight about 20-30?g. Bleomycin induces the expression levels of α-SMA and collagen I.
Bleomycin sulfate (intratracheally; 2.5?mg/kg; 1.25?mg/ml, approximately 50?µl per mouse) induces pulmonary fibrosis in male C57BL/6 mice (8?weeks old, average weight approximately 24.5?g).

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