MCE 的所有產(chǎn)品僅用作科學研究或藥證申報,，我們不為任何個人用途提供產(chǎn)品和服務。

NCB-0846

CAS No. : 1792999-26-8

產(chǎn)品活性：NCB-0846 is an orally available TNIK inhibitor with an IC₅₀ of 21?nM.

研究領域：Stem Cell/Wnt  |  MAPK/ERK Pathway

作用靶點：Wnt  |  MAP4K

In Vitro: NCB-0846 has anti-Wnt activity. NCB-0846 binds to TNIK in an inactive conformation, and this binding mode seems to be essential for Wnt inhibition. NCB-0846 shows inhibitory activity against TNIK with an IC₅₀ of 21?nM. NCB-0846 also inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK. NCB-0846 induces faster migration of TCF4 phosphorylated by TNIK within a concentration range of 0.1-0.3?μM and completely inhibits the phosphorylation of TCF4 at a concentration of 3?μM. NCB-0846 inhibits HCT116 cell growth and shows much higher (-20-fold) inhibitory activity against colony formation by the same cells in soft agar.

In Vivo: NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice. The expression of Wnt-target genes (AXIN2, MYC and CCND1) in xenografts is reduced following the administration of NCB-0846. NCB-0846 induces an increase in the sub-G1 cell population. Cleavage of poly (ADP-ribose) polymerase 1 indicates the induction of apoptosis.

相關產(chǎn)品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Neuroprotective Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Obesity Compound Library  |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Antihypertensive Compound Library  |  Membrane Protein-targeted Compound Library  |  HPK1-IN-34  |  HPK1-IN-10  |  FzM1  |  HPK1-IN-33  |  Pamidronic acid  |  HPK1-IN-25  |  Fz7-21  |  NSC668036  |  JW67  |  Ipafricept  |  Ipivivint  |  GNE-6893  |  HPK1-IN-14  |  JW74  |  IQ 1  |  Heparan Sulfate  |  GNE 220  |  L-Quebrachitol  |  ETC-159  |  HLY78  |  HPK1-IN-12  |  HPK1-IN-26  |  Cardiogenol C hydrochloride  |  Laduviglusib (GMP)  |  FzM1.8  |  OM-153  |  HPK1-IN-29  |  GNE-495  |  HPK1-IN-32  |  NLS-StAx-h TFA

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫,，我們致力于為*科研客戶提供前沿的高品質小分子活性化合物,；
•   50,000 多種高選擇性抑制劑,、激動劑涉及各熱門信號通路及疾病領,；
•   產(chǎn)品種類涵蓋各種重組蛋白,，多肽,，常用試劑盒 ,，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應用于新藥研發(fā),、生命科學等科研項目,；
•   提供虛擬篩選，離子通道篩選,，代謝組學分析檢測分析,，藥物篩選等專業(yè)技術服務；
•   設有專業(yè)的實驗中心和嚴格的質控,、驗證體系,；
•   提供 LC/MS、NMR,、HPLC,、手性分析、元素分析等各項質檢報告,，確保產(chǎn)品的高純度,、高品質；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證,；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果,；
•   專業(yè)團隊跟蹤最新的制藥及生命科學研究進展，為您提供*新的活性化合物,；
•   與世界各大制藥公司及著名科研機構建立了長期的合作,。