目錄:MedChemExpress LLC>>生化試劑>> StemRegenin 1 | MCE
CAS | 1227633-49-9 | 純度 | 99.87% |
---|---|---|---|
分子量 | 429.54 | 分子式 | C??H??N?OS |
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mg |
貨號 | HY-15001 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報,我們不為任何個人用途提供產(chǎn)品和服務(wù),。
CAS No. : 1227633-49-9
產(chǎn)品活性:StemRegenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM.
研究領(lǐng)域:Immunology/Inflammation
作用靶點:Aryl Hydrocarbon Receptor
In Vitro: StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. StemRegenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that StemRegenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, StemRegenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.
相關(guān)產(chǎn)品:Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Transcription Factor-Targeted Library | Human Metabolite Library | Heterocyclic Compound Library | PDM2 | Mivotilate | FICZ | AHR antagonist 5 | AhR modulator-1 | Indolokine A5 | Flavipin | Pifithrin-α hydrobromide | Prochloraz | L-Kynurenine | AHR antagonist 4 | ITE | Carbidopa | BAY 2416964 | Skatole-d8 | DiMNF | KYN-101 | AhR agonist 2 | β-Naphthoflavone | Carbidopa-d3 (monohydrate) | L-Kynurenine-d4-1 | (Rac)-Carbidopa-13C,d3 | CHD-5 | MeBIO | L-Kynurenine-d4 | L-Kynurenine-13C10 (sulfate) | Indole-3-carbinol
熱門產(chǎn)品線:重組蛋白 | 化合物庫 | 天然產(chǎn)物 | 熒光染料 | PROTAC | 同位素標記物 | 寡核苷酸 | 抗體 | 點擊化學(xué)
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介紹:
• MCE (MedChemExpress) 擁有200 多種*僅有化合物庫,,我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物,;
• 50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領(lǐng),;
• 產(chǎn)品種類涵蓋各種重組蛋白,,多肽,常用試劑盒 ,,更有 PROTAC,、ADC 等特色產(chǎn)品,廣泛應(yīng)用于新藥研發(fā),、生命科學(xué)等科研項目,;
• 提供虛擬篩選,離子通道篩選,,代謝組學(xué)分析檢測分析,,藥物篩選等專業(yè)技術(shù)服務(wù);
• 設(shè)有專業(yè)的實驗中心和嚴格的質(zhì)控,、驗證體系,;
• 提供 LC/MS、NMR、HPLC,、手性分析,、元素分析等各項質(zhì)檢報告,確保產(chǎn)品的高純度,、高品質(zhì),;
• 產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證;
• Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果,;
• 專業(yè)團隊跟蹤新的制藥及生命科學(xué)研究進展,,為您提供*新的活性化合物;
• 與世界各大制藥公司及*科研機構(gòu)建立了長期的合作,。