MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個人用途提供產(chǎn)品和服務(wù),。

GW788388

CAS No. : 452342-67-5

產(chǎn)品活性：GW788388 is a potent and selective inhibitor of ALK5 with IC₅₀ of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.

研究領(lǐng)域：TGF-beta/Smad

作用靶點(diǎn)：TGF-β Receptor

In Vivo: GW788388 given orally for 5 weeks significantly reduces renal fibrosis and decreased the mRNA levels of key mediators of extracellular matrix deposition in kidneys in db/db mice. GW788388 (50 mg/kg/day, p.o.) significantly attenuates systolic dysfunction in the MI animals, together with the attenuation of the activated (phosphorylated) Smad2 (P < 0.01), α-smooth muscle actin (P < 0.001), and collagen I (P < 0.05) in the noninfarct zone of MI rats. GW788388 reduces the expression of collagen IA1 by 80% at a dose of 1 mg/kg twice a day (b.i.d.). GW788388 significantly reduces the expression of collagen IA1 mRNA when administered orally at 10 mg/kg once a day (u.i.d.) in a model of puromycin aminonucleoside-induced renal fibrosis.

相關(guān)產(chǎn)品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  TGF-beta/Smad Compound Library  |  Anti-Cancer Compound Library  |  Covalent Screening Library  |  Reprogramming Compound Library  |  Chemical Probe Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Obesity Compound Library  |  Angiogenesis-Related Compound Library  |  Targeted Diversity Library  |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Osteogenesis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)  |  ML347  |  Nadecnemab  |  Zilurgisertib  |  TGFβRI-IN-3  |  Vactosertib  |  Itacnosertib  |  Trafermin  |  Maohuoside A  |  Metelimumab  |  Stamulumab  |  SB-505124 hydrochloride  |  K02288  |  J-1063  |  ALK5-IN-25  |  LY-364947  |  GW-6604  |  TP-008  |  ALK2-IN-4  |  Galunisertib  |  CJJ300  |  ALK5-IN-7  |  ALK5-IN-32  |  A 83-01  |  RepSox (GMP)  |  A 77-01  |  Dorsomorphin  |  OD36  |  BMS-986260

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點(diǎn)擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫,，我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物；
•   50,000 多種高選擇性抑制劑,、激動劑涉及各熱門信號通路及疾病領(lǐng)；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽,，常用試劑盒 ，更有 PROTAC,、ADC 等特色產(chǎn)品,，廣泛應(yīng)用于新藥研發(fā)、生命科學(xué)等科研項(xiàng)目,；
•   提供虛擬篩選,，離子通道篩選，代謝組學(xué)分析檢測分析,，藥物篩選等專業(yè)技術(shù)服務(wù),；
•   設(shè)有專業(yè)的實(shí)驗(yàn)中心和嚴(yán)格的質(zhì)控、驗(yàn)證體系,；
•   提供 LC/MS,、NMR、HPLC,、手性分析,、元素分析等各項(xiàng)質(zhì)檢報(bào)告，確保產(chǎn)品的高純度,、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實(shí)驗(yàn)驗(yàn)證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果,；
•   專業(yè)團(tuán)隊(duì)跟蹤最新的制藥及生命科學(xué)研究進(jìn)展,，為您提供*新的活性化合物；
•   與世界各大制藥公司及著名科研機(jī)構(gòu)建立了長期的合作,。