MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào),，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù),。

NSC668394

CAS No. : 382605-72-3

產(chǎn)品活性：NSC668394 is a potent ezrin (Thr567) phosphorylation inhibitor, with a K_d of 12.59 μM. NSC668394 inhibit ezrin T567 phosphorylation caused by PKCΙ primarily via their binding to ezrin. NSC668394 can be used to prevent tumor metastasis.

研究領(lǐng)域：Epigenetics  |  TGF-beta/Smad

作用靶點(diǎn)：PKC

In Vitro: NSC668394 (10 μM; pretreated for 15 min) inhibits ezrin T567 phosphorylation (IC₅₀=8.1 μM) and actin binding in vitro.
NSC668394 (1-10 μM; 2-6 h) inhibits ezrin-mediated invasion by K7M2 osteosarcoma (OS) cells on the HUVEC monolayer.
NSC668394 (20 μM) causes significant decrease in growth in JM1 and JM2 rat hepatoma cell lines.
NSC668394 (10 μM) reduces cell motility phenotypes in zebrafish.

In Vivo: NSC668394 (0.226 mg/kg/day; i.p. 5-days a week) inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung.

相關(guān)產(chǎn)品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Kinase Inhibitor Library  |  TGF-beta/Smad Compound Library  |  Anti-Cancer Compound Library  |  Oxygen Sensing Compound Library  |  Cytoskeleton Compound Library  |  Coagulation and Anti-coagulation Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  SB-218078  |  p32 Inhibitor M36  |  Staurosporine  |  N-Myristoyl-Lys-Arg-Thr-Leu-Arg  |  PF-04577806  |  Bisindolylmaleimide II  |  Hypericin  |  D-erythro-Sphingosine  |  Mitoxantrone diacetate  |  R 59-022 hydrochloride  |  Ingenol Mebutate  |  Hu7691 free base  |  1-Stearoyl-2-arachidonoyl-sn-glycerol  |  Procyanidin A1  |  Hispidin  |  Ionomycin  |  CRT0066854  |  Protein kinase inhibitor H-7  |  Spisulosine  |  1,2-Dimyristoyl-sn-glycerol  |  PKC-IN-4  |  [Ala113]MBP(104-118) TFA  |  Bryostatin 3  |  Enzastaurin  |  HA-100 hydrochloride  |  KT5823  |  Darovasertib  |  Myelin Basic Protein  |  K-252b

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點(diǎn)擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物,；
•   50,000 多種高選擇性抑制劑、激動(dòng)劑涉及各熱門信號(hào)通路及疾病領(lǐng),；
•   產(chǎn)品種類涵蓋各種重組蛋白,，多肽，常用試劑盒 ,，更有 PROTAC,、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā),、生命科學(xué)等科研項(xiàng)目,；
•   提供虛擬篩選，離子通道篩選,，代謝組學(xué)分析檢測分析,，藥物篩選等專業(yè)技術(shù)服務(wù)；
•   設(shè)有專業(yè)的實(shí)驗(yàn)中心和嚴(yán)格的質(zhì)控,、驗(yàn)證體系,；
•   提供 LC/MS、NMR,、HPLC,、手性分析、元素分析等各項(xiàng)質(zhì)檢報(bào)告,，確保產(chǎn)品的高純度,、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實(shí)驗(yàn)驗(yàn)證,；
•   Nature, Cell, Science 等多種頂級(jí)期刊及制藥 Patent 收錄了MCE客戶的科研成果,；
•   專業(yè)團(tuán)隊(duì)跟蹤最新的制藥及生命科學(xué)研究進(jìn)展,，為您提供*新的活性化合物；
•   與世界各大制藥公司及著名科研機(jī)構(gòu)建立了長期的合作,。