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Rituximab

CAS No. : 174722-31-7

產(chǎn)品活性：Rituximab is an anti-CD20 chimeric monoclonal antibody used for research of certain autoimmune diseases and cancer.

研究領(lǐng)域：Immunology/Inflammation

作用靶點：CD20

In Vitro: Rituximab inhibits the proliferation of stimulated human B cells, which is associated with a relative increase of B cells with an activated naive phenotype. Aside from this population shift, there are no major changes in phenotype or cytokine profile of the various B-cell subsets. B cells stimulated in the presence of rituximab induces stronger T-cell proliferation, compared to B cells stimulated in the absence of rituximab. All lymphoma cells tested are equally sensitive to antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-mediated phagocytosis of tumor cells, and rituximab-induced apoptosis. Rituximab induces high CDC killing of follicular lymphoma cells.

In Vivo: A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent.

相關(guān)產(chǎn)品：Plamotamab  |  Glofitamab  |  Divozilimab  |  Mosunetuzumab  |  Ofatumumab  |  Ublituximab  |  Ripertamab  |  Blontuvetmab  |  Imvotamab  |  Rituximab (anti-CD20)  |  Zuberitamab  |  Odronextamab  |  Tositumomab  |  Ocaratuzumab  |  Obinutuzumab

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