目錄:MedChemExpress LLC>>生化試劑>> Bevacizumab | MCE
CAS | 216974-75-3 | 純度 | ≥99.0% |
---|---|---|---|
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5 mg |
貨號 | HY-P9906 | 應用領域 | 醫(yī)療衛(wèi)生,化工,生物產業(yè),制藥 |
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CAS No. : 216974-75-3
產品活性:Bevacizumab, a humanized IgG1 monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity.
研究領域:Protein Tyrosine Kinase/RTK
作用靶點:VEGFR
In Vitro: Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity, and inhibits its interaction with VEGFR-1 and VEGFR-2. Experimental analysis shows that the EC50 of Bevacizumab to bind VEGF analyzed by ELISA is 0.18 μg/mL. Binding kinetics assays show similar results that Bevacizumab inhibits the VEGF-induced proliferation of HUVEC with an IC50 value of 0.047±0.0081 μg/mL.
In Vivo: It is demonstrated that the subconjunctival administration of FD006 and Bevacizumab can significantly inhibit CoNV in NaOH cauterized rats compared with the control group (p?0.01).
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