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Isosteviol

CAS No. : 27975-19-5

產(chǎn)品活性：Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects.

研究領(lǐng)域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage

作用靶點(diǎn)：Reactive Oxygen Species  |  Topoisomerase

結(jié)構(gòu)分類：萜類  |  二萜

來源：植物  |  其他科

In Vitro: Isosteviol ((-)-Isosteviol) dose-dependently relaxed the vasopressin (10^-8 M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10^-2 M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10^-8 M vasopressin.
The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca²⁺]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca ²⁺]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present.
Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II.

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