XRCC4 Polyclonal Antibody
抗體,也叫免疫球蛋白(Ig),,是一種能特異性結(jié)合抗原的糖蛋白,,而抗原是在易感染動(dòng)物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì),。在體內(nèi),,抗體是由于外源性分子的侵襲而產(chǎn)生的??贵w以一個(gè)或者多個(gè)Y字形單體存在,,每個(gè)Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈,。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來命名的,。Y字形結(jié)構(gòu)的頂端是可變區(qū),為抗原結(jié)合部位,。任何一個(gè)抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結(jié)構(gòu)上的差異),,每一個(gè)抗體的重鏈則決定了它的類或型。
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]
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