NPRL2 Polyclonal Antibody
抗體,，也叫免疫球蛋白（Ig），是一種能特異性結(jié)合抗原的糖蛋白,，而抗原是在易感染動物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì),。在體內(nèi),，抗體是由于外源性分子的侵襲而產(chǎn)生的,?？贵w以一個或者多個Y字形單體存在，每個Y字形單體由4條多肽鏈組成,，包含兩條相同的重鏈和兩條相同的輕鏈,。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū),，為抗原結(jié)合部位,。任何一個抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異），每一個抗體的重鏈則決定了它的類或型,。
function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.,similarity:Belongs to the NPR2 family.,subunit:Interacts with PDPK1.,tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested
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