VHL Polyclonal Antibody
抗體,，也叫免疫球蛋白（Ig）,，是一種能特異性結(jié)合抗原的糖蛋白，而抗原是在易感染動物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì),。在體內(nèi),，抗體是由于外源性分子的侵襲而產(chǎn)生的,。抗體以一個或者多個Y字形單體存在,，每個Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈,。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來命名的,。Y字形結(jié)構(gòu)的頂端是可變區(qū)，為抗原結(jié)合部位,。任何一個抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異）,，每一個抗體的重鏈則決定了它的類或型。
保存溫度：-20℃
免疫原詳細(xì)信息
The antiserum was produced against synthesized peptide derived from the N-terminal region of human VHL. AA range:1-50
相關(guān)試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],。
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