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廣州市碳水科技有限公司
主營產(chǎn)品： PEG衍生物,，水凝膠,，納米顆粒制備和合成服務(wù),，脂質(zhì)體和脂質(zhì)體用輔料,，核酸遞送輔料,，聚合物和共聚物,，PROTAC / ADC Linker,，多肽的定制服務(wù),，熒光染料,，點(diǎn)擊化學(xué) |
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廣州市碳水科技有限公司
主營產(chǎn)品： PEG衍生物,，水凝膠,，納米顆粒制備和合成服務(wù),，脂質(zhì)體和脂質(zhì)體用輔料,，核酸遞送輔料,，聚合物和共聚物,，PROTAC / ADC Linker,，多肽的定制服務(wù),，熒光染料,，點(diǎn)擊化學(xué) |
聯(lián)系電話
| 參考價(jià) | ￥ 99 |
| 訂貨量 | 1瓶 |
更新時(shí)間：2023-10-31 10:01:21瀏覽次數(shù)：189
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| CAS | N/A | 純度 | 95% |
|---|---|---|---|
| 分子量 | 定制 | 供貨周期 | 兩周 |
| 規(guī)格 | 50mg | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
| 主要用途 | 科學(xué)研究 |
LyP-1修飾負(fù)載核酸/藥物的靶向脂質(zhì)體
【中文名稱】
腫瘤淋巴管歸巢肽LyP-1修飾負(fù)載核酸/藥物的靶向脂質(zhì)體
【英文名稱】
Targeted liposome coated withLyP-1
【純 度】
95%以上
【保存】
4℃保存
【規(guī)格】
50mg，10mg/ml
【產(chǎn)品特性】
LyP-1 是一種環(huán)狀 9 個(gè)氨基酸的腫瘤的定位肽,，在多種腫瘤相關(guān)細(xì)胞中,，選擇性結(jié)合其 p32 receptor 蛋白。
LyP-1 (8?weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide[1].
The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.
At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×106 photon/cm2/sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide[1].
LyP-1修飾負(fù)載核酸/藥物的靶向脂質(zhì)體
LyP-1修飾負(fù)載核酸/藥物的靶向脂質(zhì)體
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腫瘤淋巴管歸巢肽LyP-1修飾負(fù)載核酸/藥物的靶向脂質(zhì)體
