CA-125 卵巢癌抗原（鼠單克隆抗體）

廣州健侖生物科技有限公司

CA125是1981年由Bast等從上皮性卵巢癌抗原檢測(cè)出可被單克隆抗體OC125結(jié)合的一種糖蛋白,，來(lái)源于胚胎發(fā)育期體腔上皮,，在正常卵巢組織中不存在,，因此zui常見(jiàn)于上皮性卵巢腫瘤（漿液性腫瘤）患者的血清中,，其診斷的敏感性較高，但特異性較差,。黏液性卵巢腫瘤中不存在,。80%的卵巢上皮性腫瘤患者血清CA125升高，但近半數(shù)的早期病例并不升高,，故不單獨(dú)用于卵巢上皮性癌的早期診斷,。90%患者血清CA125與病程進(jìn)展有關(guān)，故多用于病情檢測(cè)和療效評(píng)估。95%的健康成年婦女CA125的水平≤40U/ml,，若升高至正常值的2倍以上應(yīng)引起重視。另外CA125也可見(jiàn)于結(jié)核性腹膜炎患者的血清檢查中,，且CA125水平呈數(shù)十倍升高，在卵巢癌術(shù)前應(yīng)明確排除結(jié)核性腹膜炎可能,。

我司還提供其它進(jìn)口或國(guó)產(chǎn)試劑盒：登革熱,、瘧疾,、流感,、A鏈球菌,、合胞病毒、腮病毒,、乙腦,、寨卡,、黃熱病,、基孔肯雅熱、克錐蟲(chóng)病,、違禁品濫用,、肺炎球菌,、軍團(tuán)菌、化妝品檢測(cè),、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清,、德國(guó)SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品,。

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【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿/細(xì)胞膜

克隆號(hào)：OC125

同型：IgG1/k

適用組織：石蠟/冰凍

陽(yáng)性對(duì)照：卵巢癌/子宮內(nèi)膜癌

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

CA-125 卵巢癌抗原（鼠單克隆抗體）

抗原抗體反應(yīng)性曲霉菌病
過(guò)敏體制者吸入大量含有曲霉孢子的塵埃,，引起過(guò)敏性鼻炎、支氣管哮喘,，支氣管炎或變性肺曲霉菌病,。吸入后數(shù)小時(shí)出現(xiàn)喘息、咳嗽和咳痰,，可伴發(fā)熱,。大多數(shù)患者3—4天緩解，如再吸入又復(fù)發(fā)上述癥狀,，痰中可檢出大量嗜酸性粒細(xì)胞和菌絲。培養(yǎng)見(jiàn)煙熏色曲霉菌生長(zhǎng),，血嗜酸性粒細(xì)胞增多（>1.0×109/L）,，血清IgE>1000ng/ml。
全身性曲霉菌病
多見(jiàn)于原發(fā)性和繼發(fā)性免疫缺陷者,。曲霉菌多由肺部病灶進(jìn)入血循環(huán),，播散至全身多個(gè)臟器。白血病,、惡性淋巴瘤,、腫瘤、慢性肺部疾患,、長(zhǎng)期適用抗生素和皮質(zhì)激素等,，是發(fā)生本病的誘因。其臨床表現(xiàn)隨所侵犯的臟器而異,，臨床上以發(fā)熱、全身中毒癥狀和栓塞zui常見(jiàn),。累及信內(nèi)膜,、心肌或心包,，引起化膿,、壞死和肉芽腫,，中樞神經(jīng)系統(tǒng)受累引起腦膜炎和腦膿腫,。消化系統(tǒng)以及肝受累多見(jiàn),。
疾病病因
曲霉菌屬絲狀真菌,，是一種常見(jiàn)的條件致病性真菌,，引起人類(lèi)疾病常見(jiàn)的有煙曲霉菌和黃曲霉菌,。
曲霉菌廣布自然界，存在土壤,、空氣、植物,、野生或家禽動(dòng)物及飛鳥(niǎo)的皮毛,。也常見(jiàn)于農(nóng)田、馬棚、牛欄、谷倉(cāng)等處?？杉纳谡Ｈ说钠つw和上呼吸道,，為條件致病菌,。一般正常人對(duì)曲霉菌有一定的抵抗力，不引起疾病,。曲霉菌病大多為繼發(fā)性,，當(dāng)機(jī)體抵抗力降低時(shí),，病原菌可經(jīng)皮膚黏膜損傷處或吸入呼吸道，進(jìn)而進(jìn)入血液循環(huán)到其他組織或抗原抗體而致病。過(guò)敏體制者吸入曲霉菌孢子可觸發(fā)IgE介導(dǎo)的變化反應(yīng)而支氣管痙攣。
病理生理
曲霉菌zui常侵犯支氣管和肺,，可侵犯鼻竇,、外耳道、眼和皮膚,，或抗原抗體行播散至全身各抗原抗體,。病變?cè)缙跒閺浡越?rùn)滲出性改變；晚期為壞死,，化膿或肉芽腫形成,。病灶內(nèi)可找到大量菌絲。菌絲穿透血管可引起血管炎,、血管周?chē)?、血栓形成等，血栓形成又使組織缺血,、壞死,。

我司還提供其它進(jìn)口或國(guó)產(chǎn)試劑盒：登革熱、瘧疾,、流感,、A鏈球菌、合胞病毒,、腮病毒,、乙腦、寨卡,、黃熱病,、基孔肯雅熱、克錐蟲(chóng)病,、違禁品濫用,、肺炎球菌、軍團(tuán)菌,、化妝品檢測(cè),、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清,、德國(guó)SiFin診斷血清,、丹麥SSI診斷血清等產(chǎn)品。

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【公司名稱(chēng)】 廣州健侖生物科技有限公司
【市場(chǎng)部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

Antigen Antibody Reactivity Aspergillosis
People with allergies inhale large amounts of dust containing Aspergillus spores, causing allergic rhinitis, bronchial asthma, bronchitis, or degenerative lung aspergillosis. A few hours after inhaling wheezing, coughing and expectoration may be associated with fever. Most patients 3-4 days to ease, such as re-inhalation and relapse of the above symptoms, sputum can be found in a large number of eosinophils and hyphae. See culture of Aspergillus smithii, blood eosinophilia (> 1.0 × 109 / L) and serum IgE> 1000 ng / ml.
Systemic aspergillosis
More common in primary and secondary immune deficiency. Aspergillus into the blood circulation by the lung lesions, spread to multiple organs throughout the body. Leukemia, malignant lymphoma, cancer, chronic lung disease, long-term use of antibiotics and corticosteroids, is the cause of the disease. Its clinical manifestations vary with the organs of infringement, clinical fever, systemic symptoms and embolism most common. Endocardial involvement of the letter, myocardium or pericardium, causing purulent, necrotic and granulomatous, central nervous system involvement cause meningitis and brain abscess. Digestive system and liver involvement more common.
Etiology of the disease
Aspergillus filamentous fungus, is a common condition pathogenic fungi, caused by human diseases are common Aspergillus fumigatus and Aspergillus flavus.
Aspergillus Widely distributed in nature, there is the soil, air, plants, wild or poultry animals and birds fur. Also common in farmland, horse shed, bullpen, barns and other places. Can be parasitic on normal skin and upper respiratory tract, as a condition of pathogenic bacteria. Normal normal people have some resistance to Aspergillus, does not cause disease. Aspergillosis is mostly secondary, when the body resistance is reduced, the pathogen can be inhaled through the skin and mucosal injury or respiratory tract, and then into the blood circulation to other tissues or antigen-antibody and pathogenic. Allergic aspiration of aspergillus spores triggers IgE-mediated changes in response to bronchospasm.
Pathophysiology
Aspergillus most often violates the bronchi and lungs and can invade the sinuses, external auditory meatus, eyes and skin, or antigen-antibody lines spread to all body antigens. Early diffuse diffuse infiltration of exudative changes; advanced necrosis, suppuration or granuloma formation. A large number of mycelium can be found within the lesion. Hyphae penetrate the blood vessels can cause vasculitis, perivascular inflammation, thrombosis, thrombosis and tissue ischemia and necrosis.