AFP甲胎蛋白（兔多克隆抗體）

Alpha-Fetoprotein

廣州健侖生物科技有限公司

甲胎蛋白（AFP）是一種糖蛋白,，屬于白蛋白家族，主要由胎兒肝細(xì)胞及卵黃囊合成,。甲胎蛋白在胎兒血液循環(huán)中具有較高的濃度,，出生后則下降，至生后2～3月甲胎蛋白基本被白蛋白替代,，血液中較難檢出,，故在成人血清中含量極低。甲胎蛋白具有很多重要的生理功能,，包括運(yùn)輸功能,、作為生長(zhǎng)調(diào)節(jié)因子的雙向調(diào)節(jié)功能、免疫抑制,、T淋巴細(xì)胞誘導(dǎo)凋亡等,。甲胎蛋白與肝癌及多種腫瘤的發(fā)生發(fā)展密切相關(guān)，在多種腫瘤中均可表現(xiàn)出較高濃度,，可作為多種腫瘤的陽(yáng)性檢測(cè)指標(biāo),。目前臨床上主要作為原發(fā)性肝癌的血清標(biāo)志物，用于原發(fā)性肝癌的診斷及療效監(jiān)測(cè),。所以AFP常用于鑒定腫瘤與非腫瘤性肝臟疾病,、卵黃癌和其它細(xì)胞腫瘤。

我司還提供其它進(jìn)口或國(guó)產(chǎn)試劑盒：登革熱,、瘧疾,、流感、A鏈球菌,、合胞病毒,、腮病毒、乙腦,、寨卡,、黃熱病,、基孔肯雅熱、克錐蟲病,、違禁品濫用,、肺炎球菌,、軍團(tuán)菌,、化妝品檢測(cè)、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清,、德國(guó)SiFin診斷血清,、丹麥SSI診斷血清等產(chǎn)品。

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【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

適用組織：石蠟/冰凍

陽(yáng)性對(duì)照：胎肝

抗原修復(fù)：熱修復(fù)（檸檬酸）

抗體孵育時(shí)間：30-60min

AFP甲胎蛋白（兔多克隆抗體）Alpha-Fetoprotein

專家觀點(diǎn)
阿米巴病隨我國(guó)衛(wèi)生條件的改善和人民生活水平的提高,，發(fā)病率已經(jīng)有了非常明顯的下降,，但在門診經(jīng)常看到有患者被診斷,，并長(zhǎng)期服藥達(dá)數(shù)月,、數(shù)年之久。更有只有幾個(gè)月大的嬰兒被診斷為阿米巴病并給于抗菌素治療,。故在疾病的診斷時(shí)一定要注意病史,，如嬰兒（尤其是城市嬰兒）基本沒(méi)有可能接觸到溶組織內(nèi)阿米巴包囊，除非與之有密切者患有阿米巴??；另外，不是每種阿米巴都是可以致病的,，而患兒卻因此被給與長(zhǎng)期的抗菌素治療,，反造成腸道菌群紊亂而導(dǎo)致腹瀉加重。
阿米巴腸病是由于溶組織阿米巴（痢疾阿米巴）寄生于結(jié)腸內(nèi),，引起阿米巴痢疾或阿米巴結(jié)腸炎,。痢疾阿米巴也是根足蟲綱中zui重要的致病種類，在一定條件下,，并可擴(kuò)延至肝,、肺、腦,、泌尿生殖系和其他部位,，形成潰瘍和膿腫,。
流行病學(xué)
本病流行于*,，多流行于熱帶和亞熱帶地區(qū)。其感染率高低與各地環(huán)境衛(wèi)生,、經(jīng)濟(jì)狀況和飲食習(xí)慣等密切相關(guān),。在我國(guó)的分布一般農(nóng)村高于城市,，近年來(lái)由于我國(guó)衛(wèi)生狀況和生活水平的提高，急性阿米巴痢疾和膿腫病例,，除個(gè)別地區(qū)外,，已較為少見(jiàn)。
1.傳染源
慢性病人,、恢復(fù)期病人及健康的帶蟲者為本病的傳染源,。
2.傳播途徑
溶組織內(nèi)阿米巴的傳播方式有以下幾種：①包囊污染水源可造成該地區(qū)的暴發(fā)流行；②在以糞便作肥料,，未洗凈和未煮熟的蔬菜也是重要的傳播因素,；③包囊污染手指、食物或用具而傳播,；④蠅類及蟑螂都可接觸糞便,，體表攜帶和嘔吐糞便，將包囊污染食物而成為重要傳播媒介,。
3.流行特點(diǎn)
溶組織內(nèi)阿米巴病發(fā)布廣泛,，在溫帶地區(qū)，該病可時(shí)有流行,，而在熱帶及亞熱帶地區(qū),，其流行情況則尤為嚴(yán)重。其發(fā)病情況因時(shí)而異,，以秋季為多,，夏季次之。發(fā)病率男多于女,，成年多于兒童,，這可能與吞食含包囊的食物或年齡免疫有關(guān)。
病因
阿米巴的致病是蟲體和宿主相互作用,，并受多種因素影響的復(fù)雜過(guò)程,。溶組織內(nèi)阿米巴的侵襲力主要表現(xiàn)在對(duì)宿主組織的溶解性破壞作用。
溶組織內(nèi)阿米巴大滋養(yǎng)體,，侵襲腸壁引起阿米巴病,，常見(jiàn)的部位在盲腸，其次為直腸,、乙狀結(jié)腸和闌尾,，橫結(jié)腸和降結(jié)腸少見(jiàn)，有時(shí)可累及大腸全部或一部分回腸,。

AFP甲胎蛋白（兔多克隆抗體）Alpha-Fetoprotein

我司還提供其它進(jìn)口或國(guó)產(chǎn)試劑盒：登革熱,、瘧疾、流感、A鏈球菌,、合胞病毒,、腮病毒、乙腦,、寨卡,、黃熱病、基孔肯雅熱,、克錐蟲病,、違禁品濫用、肺炎球菌,、軍團(tuán)菌,、化妝品檢測(cè)、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清,、德國(guó)SiFin診斷血清,、丹麥SSI診斷血清等產(chǎn)品。

想了解更多的產(chǎn)品及服務(wù)請(qǐng)掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

expert's point
With the improvement of China's sanitary conditions and the improvement of people's living standard, the incidence of amebiasis has dropped significantly. However, patients are often diagnosed in outpatient clinics for several months and several years. More infants of only a few months old are diagnosed with amoebiasis and given antibiotic treatment. Therefore, in the diagnosis of the disease must pay attention to the medical history, such as infants (especially in urban infants) is unlikely to be exposed to E. histolytica amoeba cyst, unless closely followed by those with amoebiasis; In addition, not every Amoeba can be pathogenic, but children are therefore given long-term antibiotic treatment, anti-intestinal flora caused by the disorder leading to increased diarrhea.
Amoeba enteropathy is due to histolytic amoeba (dysentery amoeba) parasitic in the colon, causing amoebic dysentery or amoeba colitis. Diarrhea Amoeba is also the most important pathogenic species of the genus Footworm, under certain conditions, and can be extended to the liver, lung, brain, genitourinary tract and other parts of the formation of ulcers and abscesses.
Epidemiology
The disease is endemic in the world, more popular in tropical and subtropical regions. The prevalence of infection is closely related to the environmental health, economic conditions and eating habits in various places. In our country, the distribution of rural areas is generally higher than that of urban areas. In recent years, acute cases of amoebic dysentery and abscess have been rare in some regions, due to the improvement of China's health status and living standard.
Source of infection
Chronic patients, convalescent patients and healthy worms as the source of infection of the disease.
2. The route of transmission
Entamoeba histolytica transmission in the following ways: ① cysts contaminated water can cause outbreaks in the region; ② in the manure as fertilizer, unwashed and uncooked vegetables is also an important source of transmission; ③ Cystic contamination of fingers, food or appliances and spread; ④ flies and cockroaches can contact with excrement, body surface and vomit carrying manure will be contaminated by cystic food has become an important media.
3 popular features
Echinococcosis is widespread and in endemic areas the disease is endemic, while in the tropics and subtropics it is particularly prevalent. The incidence varies from time to time as much as in autumn, followed by summer. The incidence of male than female, adult more than children, which may be swallowed cysts containing food or age-related immunity.
Etiology
The pathogenesis of amoeba is a complex process in which the parasites interact with the host and are affected by many factors. Entamoeba histolytica invasion is mainly manifested in the dissolution of the host tissue destruction.
Entamoeba histolytica trophozoites, invasion of intestinal wall caused by amoebiasis, the common site in the cecum, followed by the rectum, sigmoid and appendix, transverse colon and descending colon rare, and sometimes can affect all or part of the large intestine ileum.