BioXCell,FGK4.5-CP133：RecombiMAb anti-mouse CD40抗體介紹

時(shí)間：2024/9/20閱讀：241

FGK4.5-CP133單克隆抗體是原始FGK4.5單克隆抗體的重組嵌合型抗體,。可變結(jié)構(gòu)域序列與原始FGK4.5克隆號(hào)相同,，但是恒定區(qū)序列已經(jīng)從大鼠IgG2a變?yōu)樾∈驣gG2a,。FGK4.5-CP133抗體像原始大鼠IgG2a抗體一樣，不包含F(xiàn)c突變,。

FGK4.5-CP133單克隆抗體能與小鼠CD40(也稱為Bp50)反應(yīng),。CD40是一種48 kDa的I型跨膜糖蛋白，屬于腫瘤壞死因子受體(TNFR)超家族,。CD40廣泛表達(dá)于抗原呈遞細(xì)胞(APCs),，如樹(shù)突狀細(xì)胞、B細(xì)胞,、巨噬細(xì)胞和單核細(xì)胞,，以及非免疫內(nèi)皮細(xì)胞,、基底上皮細(xì)胞和一系列腫瘤細(xì)胞上。CD40與其配體CD154結(jié)合后,，作為共刺激分子激活B細(xì)胞,、樹(shù)突狀細(xì)胞、單核細(xì)胞和其他APCs,。CD40在B細(xì)胞活化,、分化、增殖和免疫球蛋白同種型轉(zhuǎn)換以及樹(shù)突狀細(xì)胞成熟中起作用,。激動(dòng)性CD40單克隆抗體已被證明能激活A(yù)PCs并促進(jìn)抗腫瘤T細(xì)胞反應(yīng),。FGK4.5單克隆抗體是一種激動(dòng)性抗體，已被證明能激活表達(dá)CD40的APC,。FGK4.5單克隆抗體也可用于體外和體內(nèi)抑制CD40/CD154相互作用,。

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

產(chǎn)品詳情：

產(chǎn)品名稱	RecombiMAb anti-mouse CD40 /欣博盛生物
產(chǎn)品貨號(hào)	CP133
產(chǎn)品規(guī)格	1/5/25/50/100mg
反應(yīng)種屬	Mouse
克隆號(hào)	FGK4.5-CP133
同種型	Mouse IgG2a(switched from rat IgG2a)
免疫原	Recombinant mouse CD40 fusion protein
實(shí)驗(yàn)應(yīng)用	in vivo CD40 activation* in vitro B cell stimulation/activation* *Reported for the original rat IgG2a FGK4.5 antibody
產(chǎn)品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
純度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
無(wú)菌處理	0.2 µm filtration
純化方式	Protein G
分子量	150 kDa
小鼠病原檢測(cè)	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存條件	抗體原液保存在4°C，不能冷凍保存,。
推薦同型對(duì)照	InVivoPlus mouse IgG2a isotype control, unknown specificity（貨號(hào)BP0085）
推薦抗體稀釋液	InVivoPure pH 7.0 Dilution Buffer（貨號(hào)IP0070）

該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用,，品質(zhì)有保證，以下是部分已發(fā)表的文獻(xiàn)引用：

應(yīng)用

文章

體內(nèi)CD40激活

(in vivo CD40 activation)

1. Bauche, D., et al. (2018). 'LAG3(+) Regulatory T Cells Restrain Interleukin-23-

Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid

Cell-Driven Colitis' Immunity 49(2): 342-352 e345.

2. Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce

antitumour T-cell immunity' Nature 521(7550): 99-104.

3. Conde, P., et al. (2015). 'DC-SIGN(+) Macrophages Control the Induction of

Transplantation Tolerance' Immunity 42(6): 1143-1158.

4. Bartkowiak, T., et al. (2015). 'Unique potential of 4-1BB agonist antibody to promote

durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine' Proc

Natl Acad Sci U S A 112(38): E5290-5299.

體外B細(xì)胞刺激/激活

(in vitro B cell stimulation/activation)

1. Xu, H., et al. (2015). 'Regulation of bifurcating B cell trajectories by mutual antagonism

between transcription factors IRF4 and IRF8' Nat Immunol .

2. Muppidi, J. R., et al. (2014). 'Loss of signalling via Galpha13 in germinal centre

B-cell-derived lymphoma' Nature 516(7530): 254-258.

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

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BioXCell,FGK4.5-CP133：RecombiMAb anti-mouse CD40抗體介紹

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