血管緊張素是來源于血管緊張素原的小肽,。幾種已知的血管緊張素是調(diào)節(jié)血壓的既定內(nèi)分泌效應(yīng)物,，但它們也已知在一些器官和組織（旁分泌）和細胞水平（自分泌/內(nèi)分泌）具有其他局部功能,。血管緊張素I(DRVYIHPFHL)沒有已知的效應(yīng)器功能,，但它是血管緊張素II(DRVYIHPF)的直接前體,。血管緊張素II與AT1受體結(jié)合,，促進血管收縮,、鈉潴留、醛固酮的釋放,、氬加壓素的釋放,、細胞增生、炎癥,、纖維化,、焦慮和心臟肥大。血管緊張素A(ARVYIHPF),，和血管緊張素III(RVYIHPF),，也與AT1受體結(jié)合。血管緊張素(1-7)(DRVYIHP)結(jié)合不同的受體,，稱為MAS-1,，具有相反的作用（血管擴張、利尿,、抗擴散,、NO釋放、PGE釋放和細胞凋亡）,。血管緊張素IV(VYIHPF)與另一個稱為AT4(IRAP)的受體結(jié)合,，促進血流增加,、血管生成和利尿，它也與記憶的形成和阿爾茨海默病的發(fā)病機制有關(guān),。肽LVV-hemorphin-7（LVVYPWTQRF）不是血管緊張素,，但也能與AT4受體結(jié)合。還有其他已經(jīng)確定的血管緊張素肽,，包括Ang(1-9)(DRVYIHPFH),、Ang(1-12)(DRVYIHPFHLVI)、Ang V(3-7)(VYIHP),，以及其他幾種功能未定的短肽,。

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部分產(chǎn)品引用文獻

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6. Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling: K. Xue, et al.; Oxid. Med. Cell. Longev. 2021, 5710440 (2021)

7. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome: M. Punapart, et al.; Genes (Basel) 12, 1717 (2021)

8. B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction: T. Minato, et al.; Nat. Commun. 11, 1058 (2020)

9. Diabetes-induced Upregulation of Kallistatin Levels Exacerbates Diabetic Nephropathy via RAS Activation: Y. Yang, et al.; FASEB J. 34, 8428 (2020)

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