TL1A CHO TL1A CHO TL1A CHO
| I. Background | |
TL1A 又稱(chēng) TNFSF15，是 TNF 超家族的成員，在單核細(xì)胞,、巨噬細(xì)胞,、樹(shù)突狀細(xì)胞、 T 細(xì)胞等免疫細(xì)胞和非免疫細(xì)胞（如滑膜成纖維細(xì)胞、內(nèi)皮細(xì)胞）中均有表達(dá),。TL1A 是一 種 Ⅱ 型跨膜蛋白，通過(guò)與 TNF 同源結(jié)構(gòu)域 (THD) 相互作用自組裝成穩(wěn)定的三聚體,。它主 要以膜結(jié)合形式表達(dá),，并形成穩(wěn)定的三聚體?？扇苄?TL1A (sTL1A) 是通過(guò)可變剪接或 TNF-α轉(zhuǎn)換酶 (TACE) 裂解產(chǎn)生的,。 TL1A 競(jìng)爭(zhēng)性地與死亡受體 3（DR3）或誘餌受體 3（DcR3）結(jié)合，為下游信號(hào)通路提 供刺激信號(hào),，進(jìn)而調(diào)控效應(yīng)細(xì)胞的增殖,、活化、凋亡及細(xì)胞因子,、趨化因子的產(chǎn)生,。 | |
| II. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | TL1A（TNFSF15） |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Ligand of DR3&Binding Assay,FACS |
| III. Description of Host Cell Line | |
| Organism: | Cricetulus griseus, hamster, Chinese |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data
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