CBP10441 | |
| Gene | TP53 |
| Description | TP53, cellular tumor antigen p53, is a tumor suppressor (PMID: 30562755) involved in cell cycle arrest and apoptosis, and is the most frequently mutated gene in cancer (PMID: 10065147, PMID: 22713868). TP53 germline mutations are common in Li-Fraumeni syndrome (PMID: 30239254) and somatic missense mutations are frequent in almost all cancer types cancers (PMID: 30224644) and are also implicated in chemoresistance (PMID: 9927204, PMID: 24065105, PMID: 27066457). |
| Technical Data | |
| DNA Change | c.322_324delGGT |
| AA Change | p.G108del |
| Mutation type | In_Frame_Del |
| Zygosity | Homozygous |
| Allelic Frequency | 100.00% |
| Transcript | ENST00000420246.2 |
| Cosmic ID | COSM13119 |
| Chr position(GRCh37) | chr17:7579363_7579365 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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