| Panel-Ref® gDNA Cocktail III Reference Standard | |||||||||
| Cat No. | CBP90010 | ||||||||
| Format | Genomic DNA | ||||||||
| Description | Contains a variety of common genes, involving Mutation, Translocation, CNV, and is used as a reference material for clinical tumor-related detection. | ||||||||
| Gene | AA Change | CDS Change | Exon | Cosmic ID | Expected %AF | DdPCR %AF (n=1) | DdPCR %AF (n=2) | DdPCR %AF (n=3) | Chr position (GRCh37) |
| EGFR | p.E746_A750delELREA | c.2235_2249del15 GGAATTAAGAGAAGC>- | 19 | COSM6223 | 5 | 5 | 4.9 | 5.2 | chr7:55242465_55242479 |
| EGFR | p.L858R | c.2573T>G | 21 | COSM6224 | 5 | 4.9 | 5.1 | 4.8 | chr7:55259515 |
| EGFR | p.T790M | c.2369C>T | 20 | COSM6240 | 5 | 4.6 | 5.1 | 4.7 | chr7:55249071 |
| EGFR | p.G719S | c.2155G>A | 18 | COSM6252 | 5 | 5.6 | 5.5 | 5.2 | chr7:55241707 |
| BRAF | p.V600E | c.1799T>A | 15 | COSM476 | 內(nèi)源突變 | N/A | N/A | N/A | chr7:140453136 |
| KRAS | p.G12D | c.35G>A | 2 | COSM521 | 5 | 5 | 5.6 | 5.3 | chr12:25398284 |
| KRAS | p.Q61H | c.183A>C | 3 | COSM554 | 內(nèi)源突變 | N/A | N/A | N/A | chr12:25380275 |
| PIK3CA | p.E545K | c.1633G>A | 10 | COSM763 | 5 | 4.6 | 5 | 4.9 | chr3:178936091 |
| PIK3CA | p.H1047R | c.3140A>G | 20 | COSM775 | 內(nèi)源突變 | N/A | N/A | N/A | chr3:178952085 |
| EML4-ALK | E13-A20 | DNA Translocation | N/A | COSF408 | 5 | 4.2 | 4.6 | 4.3 | N/A |
| CCDC6-RET | E1-E12 | DNA Translocation | N/A | COSF1271 | 5 | 5.6 | 5.1 | 5.7 | N/A |
| ERBB2 | CNV | Amplication | N/A | N/A | CN=6 | CN=6.8 | CN=6.3 | CN=6.7 | N/A |
| MYC | CNV | Amplication | N/A | N/A | CN=10 | CN=9.79 | CN=10.48 | CN=9.63 | N/A |
| MSI Inspection Data | |||||||||
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| Product Information | |||||||||
| Intended Use | Research Use Only | ||||||||
| Unit Size | 1ug/vial * 1 vial | ||||||||
| Concentration | Download for COA | ||||||||
| Purity | Download for COA | ||||||||
| DNA electrophoresis | Download for COA | ||||||||
| Storage | 4°C | ||||||||
| Expiry | 36 months from the date of manufacture | ||||||||
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